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Calcium folinate is a mixture of the diastereoisomers of the 5-formyl derivative of tetrahydrofolic acid (THF). The biologically active compound of the mixture is the (-)-L-isomer, known as Citrovorum factor or (-)-folinic acid. Administration of
Calcium folinate can counteract the therapeutic and toxic effects of folic acid antagonists such as methotrexate, which
act by inhibiting dihydrofolate reductase.
â€¢ To diminish the toxicity and counteract the effect of impaired methotrexate elimination
â€¢ To treat inadvertent overdosage of folic acid antagonist
â€¢ After high dose methotrexate therapy in osteosarcoma
â€¢ To treat megaloblastic anemia due to folic acid deficiency
â€¢ To treat megaloblastic anemia of pregnancy and infancy
â€¢ For use in combination with 5-fluorouracil to prolong survival in the palliative treatment of patients with advanced colorectal cancer
LeufolÂ® 50 mg/5 ml vial for injection: Each box contains 1 vial in a plastic tray.
LeufolÂ® 100 mg/10 ml vial for injection: Each box contains 1 vial