Isentin M^®

Linagliptin+Metformin

Description
Isentin-M® combines two antihyperglycemic agents with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes: Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin hydrochloride, a member of the biguanide class. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are
released by the intestine throughout the day and levels are increased in response to a meal. These hormones are rapidly
inactivated by the enzyme, DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation
of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 & GIP increase insulin synthesis & release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, Linagliptin increases insulin release & decreases glucagon levels in the circulation
in a glucose-dependent manner. The pharmacologic mechanism of action of Metformin is different from other
classes of oral antihyperglycemic agents. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose & increases peripheral glucose uptake and utilization.

Indication
Isentin-M® is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes
mellitus when treatment with both Linagliptin & Metformin is appropriate.

Supply
Isentin-M® 2.5/500 Tablet: Each box contains 3x10's tablets in Alu-Alu blister pack.
Isentin-M® 2.5/850 Tablet: Each box contains 5x6's tablets in Alu-Alu blister pack.
Isentin-M® 2.5/1000 Tablet: Each box contains 5x6's tablets in Alu-Alu blister pack.