Losacor plus

Losartan + Hydrochlorothiazide

Description
Losartan and its active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Both losartan and its principal have much greater affinity (about 1000-fold) for the AT1 receptor than for the AT2 receptor.

Hydrochlorothiazide is a thiazide diuretic. It affects the renal tubular mechanisms of electrolyte reabsorption, directly increasing the excretion of sodium and chloride. Indirectly, the diuretic action of Hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decrease in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist (Losartan) tends to reverse the potassium loss associated with thiazide diuretics.

Indications
Hypertension
Losacor plus (Losartan & Hydrochlorothiazide) is indicated for the treatment of hypertension.

Type 2 Diabetic Patients with Proteinuria and Hypertension
Losacor is also indicated to delay the progression of renal disease, end stage renal disease, and to reduce proteinuria.

Hypertensive Patients with Left Venticular Hypertrophy
Losacor plus is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.

Supply
Losacor plus: 5x6’s tablet in alu-alu blister.