Darbetin

Darbepoetin alfa

Description
Darbepoetin alfa is an erythropoiesis stimulating protein, closely related to erythropoietin that is produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. Darbepoetin alfa is a 165-amino acid protein that differs from recombinant human erythropoietin in containing 5 N-linked oligosaccharide chains, whereas recombinant human erythropoietin contains 3 chains. The two additional N glycosylation sites result from amino acid substitutions in the erythropoietin peptide backbone. The additional carbohydrate chains increase the approximate molecular weight of the glycoprotein from 30,000 to 37,000 Daltons. Darbepoetin alfa is formulated as a sterile, colorless, preservative-free protein solution for intravenous (IV) or subcutaneous (SC) administration.

Indication
Treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adults and paediatric patients (both dialysis and non-dialysis).

Treatment of symptomatic anaemia in adult cancer patients with non-myeloid malignancies receiving chemotherapy.

Supply
Darbetin 25 microgram solution for injection in pre-filled syringe: Each box contains 1 pre-filled syringe containing 0.42 ml sterile solution of 25 microgram of Darbepoetin alfa INN and an alcohol pad.
Darbetin 40 microgram solution for injection in pre-filled syringe: Each box contains 1 pre-filled syringe containing 0.4 ml sterile solution of 40 microgram of Darbepoetin alfa INN and an alcohol pad.
Darbetin 60 microgram solution for injection in pre-filled syringe: Each box contains 1 pre-filled syringe containing 0.3 ml sterile solution of 60 microgram of Darbepoetin alfa INN and an alcohol pad.
Darbetin 100 microgram solution for injection in pre-filled syringe: Each box contains 1 pre-filled syringe containing 0.5 ml sterile solution of 100 microgram of Darbepoetin alfa INN and an alcohol pad.