Combicard^®

Amlodipine + Atenolol

Description
Combicard is a fixed-dose combination of Amlodipine and Atenolol. Amlodipine is a dihydropyridine calcium antagonist that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle; it has a greater efffect on vascular smooth muscle than on cardiac muscle. Amlodipine is a peripheral vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Amlodipine reduces tone, decreases coronary vasoreactivity and lowers cardiac demand by reducing after load. Atenolol is a cardioselective beta-blocker. The cardio-selectivity is doserelated. Atenolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Atenolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects.

Indications
Patients with hypertension, angina pectoris & hypertension as co-existing diseases, post MI, refractory angina pectoris where nitrate therapy has failed.

Supply
Combicard^® Tablet: Each box contains 3x10s tablets in blister pack.